Pathological changes of the testes after scalding in rats
- VernacularTitle:大鼠严重烫伤后睾丸病理变化的实验研究
- Author:
Liang WANG
;
Yisheng CHEN
- Publication Type:Journal Article
- Keywords:
scalding;
testis/PA;
testis/UL;
testosterone;
luteinizing hormone
- From:Journal of Third Military Medical University
1988;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
In the 30-day period after the rats were inflicted with 30% TBSA full thickness scalding, the main pathological changes of the testes were various degrees of degeneration and necrosis of the spermatogenic cells, Sertoli's cells, lamina propria of the seminiferous tubules and Leydig's cells. The damages on spermatogenic cells, spermatocytes and spermatids were quite severe while spermatogonial cells exhibited little damages. On the 30th day after scalding, the spermatogenic cells restored their normal morphology. The activity of 3?-hydroxy steroid dehydrogenase was rapidly reduced and remained at a relatively low level on the 30th day after scalding. The serum level of testosterone was decreased and remained at a comparatively low level on the 30th day after scalding. No significant changes of serum luteinizing hormone was observed.It is believed that the damages on the lamina propria of the seminiferous tubules and Sertoli's cells espercially the latter could change the microenvironment of the development and differentiation of the spermatogenic cells and the decrease of serum testosterone might result from the increase of glucocorticoids after scalding.
