Effects of parathyroid hormone on calcium transsacolemma in cultured heart cells
- VernacularTitle:甲状旁腺素对心肌细胞Ca~(2+)跨膜转运的影响
- Author:
Jinxuan CHENG
;
Yibin ZHANG
;
Zhengang WANG
;
Jinhong DUAN
- Publication Type:Journal Article
- Keywords:
bPTH_(1-34);
cultured heart cells;
calcium influx;
calcium efflux;
cAMP
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to obtain some evidences of the role of parathyroid hormone (PTH) in regulating calcium metabolism, and explore the mechanisms by which PTH regulates calcium in the heart, 45Ca was used to study the influence of bovine PTH1-34 fragment (bPTH1-34) on calcium transsacolemma. The results indicate that bPTH1-34(l?I0-7mol ? L-1) increases beating rate of heart cells under normal state and it markedly increases the rapid (5 min) and the slow (120 min) phases of 45Ca influx in heartcells (under normal, KC1 10-5 mol?L-1 high K+depolarised, NA 10-7mol?L-1receptors activated states), but it could also reduce 45Ca efflux from the cultured heart cells. It suggests that the mechanisms caused by bPTH1-34 which enhances the cytosolic calcium concentration and myocardial beating rate may be related with cAMP level elevated in heart cells.
