Effects of Rhynchophylline and Isorhynchophylline on the (45)~Ca-transportation in rabbit aorta
- VernacularTitle:钩藤碱和异钩藤碱对~(45)Ca转运的影响
- Author:
Xienan HUANG
;
Jinshan SHI
;
Xiaolong XIE
- Publication Type:Journal Article
- Keywords:
Rhynchophylline;
Isorhynchophylline;
(45)~Ca-influx voltage-dependent Ca~(2+) channel;
vascular smooth muscle
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of Rhynchophylline (Rhy) and Isorhychophyiline (Isorhy), the alkaloids abstracted from the Chinese traditional herb Uncaria rhynchophyllia (Miq) Jackson, on the 45Ca-influx and efflux were investigated in rabbit aorta. Both Rhy and Isorhy (10 ?mol? L-1) inhibited the 45Ca-influx induced by high K+(77. 0 mmol ? L-1), but neither significant-ly influenced the 45Ca-influx and efflux induced by noradrenaline (10 ?mol ? L-1). The results suggest that these alkaloids block the Voltage-dependent calcium channel.
