Comparative effects of nitroglycerin and nicorandil on conroary circulation in ischemic region in dogs
- VernacularTitle:硝酸甘油和尼可地尔对缺血区冠脉循环作用的比较
- Author:
Shiliang CHEN
;
Zhijie LI
- Publication Type:Journal Article
- Keywords:
coronary stenosis;
myocardial ischemia coronary blood flow;
nitroglycerin;
nicorandil
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
To comparet the role of nitrogly-cerin with nicorandil in relieving myocardial ischemia, a critical stenosis of the left anterior descending coronary artery was produced by an ex-ternal micrometer constrictor in 18 open chest dogs. Intracoronary infusion of nitroglycerin ( 1 ?g ? kg-1 ? min-1) had two effects: decreasing large coronary artery resistance (RL) and small coronary artery resistance (Rs) and increasing coronary blood flow (CBF) in first 5 min so as to relieve myocardial ischemia; then increasing RL, decreasing CBF and increasing whole blood viscosity (?o) and hematocrit (Hct) in coronary vein after 10 min so as to worsen myocardia ischemia. However, intracoronary infusion ofnicorandil(l ?g ? kg-1 ? min-1) increased CBF and decreased Rs and reduced ?o and Hct in coronary vein. The vasodilatory effect of nico-randil was moderate but long-lasting and it improved blood supply to the ischemic region in coronary circulation.
