Protective effects of naloxone on the myocardial postischemic reperfusion injury in isolated rat hearts
- VernacularTitle:纳洛酮对离体大鼠心脏缺血再灌流损伤的保护作用
- Author:
Ningping LU
;
Jimao WU
- Publication Type:Journal Article
- Keywords:
Naloxone;
Myocardium;
Ischemia and reperfusion
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
In the Langendorff's perfused isolated rat hearts, the myocardial postischemic reperfusion injury was induced by reperfusion for 30 min after stoppage of perfusion for 40 min. The effects of naloxone on the lactic acid dehydrogenase (LDH) content, the myocardial Ca contents, the myocardial malondialdiehyde (MDA) production and the myocardial superox-ide dismutase (SOD) activity were observedduring reperfusion. The results show that naloxone significantly decreased cardiac LDH release, attenuated myocardial Ca accumulation, reduced MDA production and prevented redution of SOD activity in comparison with the control in perfused isolated rat hearts with global ischemia (40 min) and reperfusion (30 min). It suggests that naloxone has protective effects on myocardial reperfusion injury.
