Effects of total glucosides of paeony on sleep-waking rhythm in rats
- VernacularTitle:白芍总甙对大白鼠睡眠节律的影响
- Author:
Anping ZHANG
;
Minzhu CHEN
;
Shuyun XU
- Publication Type:Journal Article
- Keywords:
TGP;
EEG;
EMC;
SWS;
PS
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Total glucosides of paeony (TGP, 50 mg/kg 7d, ig) could enhance the episode duration of slow-wave sleep (SWS) in normal rats, and restore the sleep parameters in the insomniac rats induced by caffeine ( 1 2. 5 mg/kg 7 d,ip)nearly to the normal level. It (50 mg/kg 3 d,ig) also increased significantly thetotal time of SWS and paradoxical sleep (PS) in the swimming rats (water temperature 25?1℃, swimming time 30 min). These results suggest that TGP probably improve the sleep of rats under the different states.
