Can Carbohydrate-Deficient Transferrin (CDT) Reflect Alcohol Consumption in Korean Male Drinkers?.
- Author:
Jong Sung KIM
1
;
Mi Kyoung OH
;
Sung Soo KIM
;
Byoung Kang PARK
;
Jin Kyu JUNG
;
Kye Chul KWON
;
Jong Woo PARK
;
Gap Jung KIM
Author Information
1. Department of Family Medicine, Chungnam National University Hospital, Daejeon, Korea. jskim@cnuh.co.kr
- Publication Type:Original Article
- Keywords:
alcohol consumption;
CDT;
AST;
ALT;
GGT
- MeSH:
Alcohol Drinking*;
Biomarkers;
Drinking;
Drinking Behavior;
Humans;
Korea;
Male*;
Transferrin*
- From:Journal of the Korean Academy of Family Medicine
2005;26(8):451-455
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: It has been suggested that CDT is a potential biological marker in the Western countries to reflect the degree of past alcohol consumption. This study was performed to compare CDT, AST (aspartate transaminase), ALT (alanine transaminase), and GGT (gamma- glutamyl transferase) as a biological marker reflecting drinking amounts in Korean patients. METHODS: The 25 males with moderate drinking(<14 drinks/week) and 26 males with heavy drinking (>21 drinks/week) were studied for the relationships between their weekly drinking amount and the blood levels of CDT, AST, ALT, and GGT. RESULTS: Only CDT was significantly correlated (P=0.001) with weekly drinking amount among heavy drinkers, while both CDT (P=0.029) and GGT (P=0.000) were significantly correlated in moderate drinkers. Stepwise multiple regression revealed that GGT had R2 of 49.1% in moderate drinkers and CDT had R2 of 38.9% in heavy drinkers for the weekly drinking amount. CONCLUSION: The results described above suggested that CDT can be a potential biological marker for the purpose of quantitative monitoring the drinking behavior of heavy drinkers in Korea.
