THE CHANGE IN FLOW DISTRIBUTION AND THE EFFECT OF POLYGONUM CUSPID ATUM ON RAT MICROVASCULATURE DURING HEMORRHAGIC SHOCK
- VernacularTitle:休克大鼠微循环中白细胞流动分布的变化及虎杖4号的治疗作用
- Author:
Yong JIANG
;
Kesen ZHAO
- Publication Type:Journal Article
- Keywords:
Microcirculation;
Hemorrhagic shock;
Polygonum cuspidatum;
Leukocyte-endothelium interaction
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The flow distribution of leukocytes in the microvasculature of rat skeletal muscle during hemorrhagic shock was measured by Microcirculation Image Multiple Parameters Computer Analysis System (MIMPCAS). It was found that the change of leukocyte flow distribution had taken place in V3 during hemorrhagic shock as follows: central axial-flowing leukocytes moved slowly, marginated to the vessel wall then started to roll along the wall, and stuck to the endothelium at last. During transfusion blood flow became faster, sticking leukocytes were rushed out to be rolling along the vessel wall and accelerated to enter the central stream. Total leukocyte -endothelium contact time (TLECT), which is a quantitative index for leukocyte endothelium interaction, is calculated, and it was found that TLECT was prolonged in shock state. The results show that it is not enough to increase blood pressure and shear stress to liberate sticking leukocytes, and it is necessary to search for a new approach to decrease the adhesive force between leukocyte and endothelium. Polygonum cuspidatum may not only increase wall shear rate but also decrease the adhesive force.
