Catecholamines: Important Factors in the Increase of Oxidative Phosphorylation Coupling in Rat-liver Mitochondria during the Early Phase of Burn Injury
- VernacularTitle:大鼠烫伤早期肝线粒体氧化磷酸化偶联增强与体内儿茶酚胺类释放的关系
- Author:
Lin YANG
;
Xuemin WANG
;
Kerning CHEN
- Publication Type:Journal Article
- Keywords:
burns;
mitochondria;
oxidative phosphorylation;
catecholamines
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The respiratory control ratio (RCR), the rate of O2 consumption in state 3 and the rate of ATP formation of liver mitochondria succinate respiratory chain were increased 30 min after Sprague-Dawley rats were injected with epinephnne or norepinephrine. The rate of O2 consumption in state 4 was increased or slightly increased. When rats were injected with adrenergic blocking agents, timolol and phenoxybenzamine, 1 h before burn, the activities of succinate respiratory chain were partly inhibited 30 min post-burn. All the results suggest that catecholamines play a main role in the increase of oxidative phosphorylation coupling in the early phase of burn injury.
