Extracellular Matrix in Liver: Experimental Study and Clinical Application
- VernacularTitle:肝间质成分层粘连蛋白和透明质酸的研究及临床应用
- Author:
Feng GAO
;
Xiantao KONG
;
Yinghua XIE
;
Xiaoli WANG
;
Lieying FAN
;
Jinxing TAN
- Publication Type:Journal Article
- Keywords:
exlracellular matrix;
laminin;
hyaluronic acid;
liver cells;
liver fibrosis
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Laminin(LN) and hyaluronie acid (HA) are extracellular matrix in liver. The effects of LN and HA on human fetal liver cells proliferation and collagen synthesis were observed and serum levels of LN and HA were assayed m patients with liver diseases by an enzyme immunoassay method. Both LN and HA had a significant effect on the inhibition of cell proliferation and collagen production. However, serum levels of LN and HA were significantly increased in liver cirrhosis comparing with healthy controls and with patients with non-liver diseases. The results suggest that LN and HA may play a role in the feed-back inhibition mechanism in liver fibrogencsis, and assay of LN and HA in serum may be useful to the diagnosis of liver fibrosis.