The significance of congenital small nevus in the pathogenesis of malignant melanoma
- VernacularTitle:先天性小痣在恶性黑素瘤发生中的地位
- Author:
Tianwen GAO
;
Rongqing LIU
;
Qingyi YE
- Publication Type:Journal Article
- Keywords:
nevus;
pigmented;
melanoma
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
There are controversies concerning whether congential small nevus(CSN)is liable to undergo malignant degeneration and whether it should be resected promptly.The signif-icane of CSN in the pathogenesis of malignant melanoma(MM)was assessed with microspec-trophotometric determination of DNA quantity,the detection of the gene product of N-ras,p21 protein,with ABC technique,ultrastructural study of MM tissue with electron microscopy,and analysis of clinical data of MM.The findings were as follows:(1)The DNA content increased sequentially in order of acquired nevus(AN),CSN,congenital giant nevus(CGN)and MM,and the difference was statistically significant among the 4 groups(P
