Establishment and genetic checkup of an inbred strain of DXB/c mouse
- VernacularTitle:DXB/c近交系小鼠的建立及遗传学检测
- Author:
Hong WEI
;
Jianhua ZHOU
;
Rong NIU
;
Bingbo CHEN
;
Shurong CHEN
- Publication Type:Journal Article
- Keywords:
mice, inbred strains;
mice, inbred DBA;
mice, inbred C_(57)BL;
genetics
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
An inbred strain of DXB/c mouse has been established by hybridization between DBA/2 female mice and C57BL/6 male ones and subsequently by sibmating their offsprings beginning from the F2 generation.Now DXB/c mouse has been passed for 28 generations of full sibmating since 1979.Genetic checkup by means of skin grafting,mandibular morphology analysis,mixed lymphocyte cultivation,coat colour gene testing,and biochemical marker gene examination confirmed that the full homozygosity of alleles has been achieved in DXB/c mouse and DXB/c mouse comforms to the criteria of an inbred strain of mouse.In addition,the genetic background of DXB/c mouse is composed of the genes of its progenitors DBA/2 and C57BL/6 as shown by coat colour gene testing and biochemical marker gene examination.
