Experimental study of atherosclerosis ⅣChanges of aortic smooth cell proliferation, platelet free calcium and aggregation in atherosclerotic rabbits and the effects of 8501 on these changes.
- VernacularTitle:动脉粥样硬化的实验研究 Ⅳ动脉粥样硬化家兔主动脉平滑肌细胞增殖和血小板胞浆游离钙水平的改变
- Author:
Zhong WANG
;
Yanhua HU
;
Guoqiang ZHU
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
aortic smooth muscle cell;
calcium;
platelet aggregation
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Smooth muscle cell (SMC) proliferation, platelet free calcium level and aggregation of experimental atherosclerotic rabbits were investigated in this study. Aortic SMC ofhyperlipidemic rabbits in vitro showed higher growth activity than did normal rabbit SMC. And also hyperlipidemic serum stimulated SMC to proliferate at a significantly greater rate than control serum. Moreover, the level of platelet free calcium and the platelet aggregation was also higher in hyperlipidemic rabbits, indicating that activitated platelets possibly release more PDGF to act as a stimulator to SMC proliferation and calcium is an important factor to activate platelets. Furthermore, SMC from 8501-treated rabbits appeared lower proliferative rate than thecells from hyperlipidemic rabbits. And serum from those rabbits inhibited SMC proliferation compared with hyperlipidemic serum, the inhibitory effect was even stronger than that of normal serum. It may be relevant to the favorable effects of 8501 to TXA2/PGI2 balance.
