Anti-arrhythmia and anti-lipid peroxidation effect of Quinidine and Cimetidine
- VernacularTitle:奎尼丁和西米替丁的抗心律失常与抗脂质过氧化作用
- Author:
Youling JING
- Publication Type:Journal Article
- Keywords:
Quinidine;
Cimetidine;
adrenaline;
arrhythmia;
lipid peroxidation
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The content of malondialdehyde (MDA) , a metabolite of lipid peroxide (LPO) , in plasma and tissue homongenate from rabbits with arrhythmias induced by adrenaline (Adr) was determined. The results showed that the MDA level was increased in plasma and tissue homogenate. Quinidine (Qui) 6 mg ? kg-1, Cimetidine (Cim) 37. 5 mg?kg-1, and 1/2 dose of both drugs administered intravenously couldsignificantly prevent ventricular arrhythmias induced by Adr and inhibit the production of MDA. The findings suggest that the effect of Qui and Cim on arrhythmias induced by Adr may associate with its inhibition on lipid peroxi-dation.
