The effects of tetramethylprazine on pancreatic blood flow in acute pancreatitis in rats and its therapy
- VernacularTitle:川芎嗪对急性胰腺炎大鼠胰腺血流量影响与治疗作用
- Author:
Xingpeng WANG
;
Yaozong YUAN
;
Jiayu XU
- Publication Type:Journal Article
- Keywords:
pancreatitis;
tetramethylpyrazine;
blood circulation;
eicosanoids
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of tetramethylpy-razine (TMP) on pancreatic blood flow and survival rate were studied in sodium tarocholate-in-duced acute pancreatitis (AP) in rats. The results showed that pancreatic relative blood flow and pancreatic tissue perfusion were significantly increased and the pathologic changes and survival rate were improved in TMP treated group-s. Plasma value of TXB2?6-Keto-PGF1? and platelet aggregation rate (PAR) were also mea-sured. We found that TMP could maintain the balance between TXA2 and PGI2 and lower the elevated PAR. It was suggested that TMP has therapeutic effect on AP in rats through improving pancreatic microcirculation; which was related to the maintanance of the balance between PGI2 and TXA2.
