The protective effect of peptide 6A on isoproterenol-induced myocardial damage in rat
- VernacularTitle:肽6A对大鼠异丙肾上腺素心肌损伤的治疗作用
- Author:
Xinghai YAO
;
Hui LI
;
Aihua FU
- Publication Type:Journal Article
- Keywords:
peptied 6A;
isoproterenol;
myocardial necrosis;
myocardial protection
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Cardio-protective action of synthetic peptide 6A, fibrinogen degradation segment, was observed on the myocardial injury model produced by subcutaneous injection of iso-proterenol (30 mg?kg-1-d-1) into rat. Treatment with peptide 6A (50 ?mol?kg-1? d-1,iv) significantly ameliorated isoproterenol-induced myocardial lesion, inhibited release of myocardial creatine phosphokinase, ?-hydroxybutyratedehydrogenase, lactate dehydrogenase and gluta-mate-oxaloacetate transaminase, lowered plasma fibrinogen content,and markedly prevented myocardial calcium accumulation. The results suggest that peptide 6A could have potential significance for clinical therapy of ischemia heart diseases.
