Effects of lappaconitine on the toxicity and analgesic activity of 3-acetylaconitine in their combination
- VernacularTitle:伍用刺乌头碱对3-乙酰乌头碱毒性及镇痛作用的影响
- Author:
Peide WANG
;
Xuemin MA
;
Yurong YANG
- Publication Type:Journal Article
- Keywords:
lappaconitine;
3- acetylaconitine;
arrythmia;
toxicity;
analgesia
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Lappaconitine (LA) 0. 5 mg? kg-1had significant antagonistic action on the ar-rythmia induced by 3-acetylaconitine ( AA ) 0.07 mg?kg-1in rat. When LA and AA were used in combination (7:1) in mice, the analgesic activity of AA was not influenced marked-ly by LA but the LD50 of AA was increased by 50% ,therefore the therapeutic index of AA was increased and the margin of safety was widened.
