PURGING OF HUMAN LEUKEMIC CELL LINES IN VITRO WITH PHOTOCARCINORIN-MEDIATED PHOTOSENSITIZATION
- VernacularTitle:癌光啉-光照体外净化人白血病细胞的研究
- Author:
Jianmin WANG
;
Peilin MENG
;
Chuansheng LI
- Publication Type:Journal Article
- Keywords:
Purging bone marrow in vitro;
Photocarcinorin;
Leukemic cell lines;
Autologous bone marrow transplantation
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
5.16 log of K562, U937, HIMeg and HL60 cells, respectively, but spare 23.37 ? 25.66% of normal CFU-GM (0.63 log killing). When HL60 cells mixed with normal mononucleated bone marrow cells in 1:9 ratio were studied, the killing of HL60 colonies was more than 4.29 log. The result suggested that photocarcinorin plus light could eliminate leukemic progenitors, and might be used in clinical ABMT. Several factors that might affect the photosensitization effect on cells were discussed.
