AN EXPERIMENTAL STUDY OF THE PATHOGENIC EFFECTS OF MULTIELEMENT CONTENTS AND ITS PATTERNS IN FEEDS FROM KESHAN DISEASE AREA IN RATS
- VernacularTitle:克山病病区粮中多元素含量及构成对动物致病作用的研究
- Author:
Cuiqing CHANG
;
Yin SU
;
Zhongbo WANG
;
Xuesong LU
;
Jing ZHANG
- Publication Type:Journal Article
- Keywords:
Keshan disease multielement constituent free radical
- From:
Acta Nutrimenta Sinica
1956;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenic effects of crops from Keshan disease area were studied by rat-feeding. As double controls, another two groups were fed with crops from non-endemic area and synthetic diet. Those from disease area caused necrosis of heart muscle vascular changes of myocardial mitochondria and fatty degeneration of liver. Compared with the controls, the free radical and lipid peroxide content in heart and liver were significantly higher, while the ATP and AN contents in these organs were apparently lower. The multielement contents and its constituent patterns in the feeds, whole blood, heart, liver, kidney and brown adipose tissue of rats in experimetal group were apparently different from those in the control groups. The statistic analysis of multiple factors showed that eight elements Se, Mo, Cu, Mn, Cr, Fe, Zn and Pr might be the perilous factors, that is, under the condition of low selenium, the constituent pattern of selenium and the eight elements might be the complicated factors of endemic crops.
