Immunohistochemical Detection of ras P_(21) Expression in Pancreatic Adenocarcinoma and Its Clinicopathological Significance
- VernacularTitle:Ras P_(21)在胰腺癌组织中的表达及其临床病理学意义
- Author:
Yuxin HU
;
Guoming XU
- Publication Type:Journal Article
- Keywords:
pancreatic adenocarcinoma;
immunohistochemistry;
antibody, monoclonal;
human
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
By using antr-ras P21 mouse monoclonal (MoAb), SCI-Oncogema 1, the authors examined immunohistochemica! staining in pancreatc adeocarcinoma. The percentage of positive staining was 24/43 (558%). Furthermore it was indicated that the positive staining rate of antr-ras P21 MoAb was related to either histopathological grade or clinical stage. Upon statistical analysis of the correlation between the staining of anti-ras P21 and patient prognosis with Kaplan-Meier curve and Log-rant test, the positive staining cases showed comparatively better prognosis than the negative ones. Our study suggests that ras P21 expression may be important in the early stage of pancreatic carcinoma.
