Effects of Central-administered Ketanserin on Blood Pressure Variability and Baroreflex Function in Conscious Rats
- VernacularTitle:酮舍林侧脑室给药对清醒大鼠血压波动性及动脉压力感受性反射的影响
- Author:
Yong CHENG
;
Xianbo KONG
;
Dingfeng SU
- Publication Type:Journal Article
- Keywords:
blood pressure;
antihypertensive agents;
hemodynamics;
hypertension;
rats
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Using computerized analysis of hemodynamics in conscious unrestrained rats, we tested the effects of intracerebroventricular administration of ketanserin (50 ?g), a special 5-HT2 antagonist, on blood pressure (BP), blood pressure variability (BPV), baroreflex-blood pressure control (ABR-BP), and baroreflex-heart period control (ABR-HP). The result are as follows: (1) There was no significant depression of blood pressure after intracerebroventricular administration of ketanserin; (2) Ketanserin could significantly decreased BPV, and enhanced ABR-BP and ABR-HP; (3) The decreasing of BPV was associated with enhancement of ABR-BP, but these changes were no related to the level of BP, indicating that the hypotension induced by ketanserin was not related to the enhancement of ABR-BP; (4) There was no significant negative relationship between ABR-BP and BPV after intracerebroventricular administration of ketanserin.
