The Measurement of NK Cells Activity and Interferon Titers in Murine Coxsackievirus B_3 Induced Myocarditis
- VernacularTitle:实验性小鼠柯萨奇B_3病毒心肌炎自然杀伤细胞活性和干扰素测定
- Author:
Qian SHEN
;
Meixian WANG
;
Tonghua ZHANG
- Publication Type:Journal Article
- Keywords:
Coxsackie B viruses;
myocarditis;
interferon;
killer cell, natural;
animal;
mice
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The level of interferon (IFN) in serum and homogenized cardiac tissue, and the activity of natural killer cells in Coxsackievirus B3 induced myocarditis in BALB/c mice were determined. NK cell cytolytic activity and IFN titers peaked on day 3~ 7 postinoculation (p.i.) and then declined. Virus titers in heart tissue reached a maximum on day 7 p.i. and then declined. These results suggest that the increase of NK cell activity and IFN titers provides some protection against Cox B, induced myocarditis by limiting virus replication in heart tissue.
