Protective Effect of Controlled Reperfusion with Warm Blood Cardioplegic Containing Mannitol on Mitochondrial Function after Myocardial Ischemia
- VernacularTitle:含甘露醇的温血停搏液控制性再灌注对缺血再灌注心肌线粒体功能的保护作用
- Author:
Long CHEN
;
Baoren ZHANG
;
Jialin ZHU
;
Rukun CHEN
;
Jiahua HAO
- Publication Type:Journal Article
- Keywords:
reperfusion;
myocardial ischemia;
mitochondria;
malondialdehyde;
superoxides dismutase;
animal;
cats
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
This study tested the hypothesis that controlled reperfusion with warm blood cardioplegia containing mannitol would result in more effectively improved recovery of myocardial mitochondrial function by preventing or reducing a potentially harmful component of reperfusion. Myocardial mitochondrial function was significantly depressed after 60 min reperfusion, but slightly depressed in the controlled reperfusion group. Significantly increased MDA content and decreased SOD activity were observed after 60 min reperfusion. Hearts in the controlled reperfusion group had low MDA content and might protect the activity of SOD. The- results indicate that controlled reperfusion after ischemia provides benefit in avoiding myocardial mitochondrial reperfusion injury.
