Effects of Dazoxiben, a Selective Thromboxane Synthetase Inhibitor, on Reperfusion Arrhythmias in Rats
- VernacularTitle:血栓素合成酶抑制剂哒唑氧苯对大鼠缺血再灌注性心律失常的影响
- Author:
Xianxian ZHAO
;
Tonghua ZHANG
;
Yongwen QIN
;
Bingyan ZHOU
;
Hongjun DING
- Publication Type:Journal Article
- Keywords:
thromboxane A2;
dazoxiben;
myocardial reperfusion;
arrhythmia;
animal;
rats
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
We studied the effects of the selective thromboxane synthetase inhibitor, dazoxiben (UK-37 248), on the reperfusion arrhythmias induced by ischemia-reperfusion in rats. The results indicated that the administration of dazoxiben (2.5 mg/kg i.v.) 15 min prior to coronary occlusion significantly decreased the incidence of ventricular fibrillation induced by 5 inin ischemia and reperfusion from 11/13 in control to 4/13 in drug-treated (P
