The Pharmacokinetics of Thyrotropin-releasing Hormone in Rabbits
- VernacularTitle:TRH在兔体内的药代动力学
- Author:
Jinger XIE
;
Keyi XU
;
Bixue WU
;
Li CHEN
;
Min YIN
;
Xilin LIAO
- Publication Type:Journal Article
- Keywords:
thyrotropin-releasing hormone;
pharmacokinetics;
animal;
rabbits
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The pharmacokinetics of thyrotropirrreleasing hormone (TRH) made in China was studied in rabbits. TRH concentrations in plasma, urine and various tissues were measured by RIA. After intravenous injection of TRH, the plasma concentration-time curve was shown to fit a two compartment open model with the following pharmacokinetic parameters: 0.8 mg/kg, T1/2?=0.551 min, T1/2? = 9.374 mm, VI = 3.018 ml/kg, Vb = 22.659 ml/kg and AUC = 0.479g. L-1. m-1; 2.0mg/kg, T1/2? = 0.629 mm, T1/2?= 9.734 min, VI = 5.135 ml/kg, Vt = 28.848 ml/kg, and AUC = 0.962g. L-1. m-1; 5.0mg/kg, T1/2? =0.720 min, T1/2?= 10.738 min, VI = 6.120 ml/kg, Vb = 31.928 ml/kg and AUC=2.540 g. L-1. m-1. TRH was distributed widely in tissues and concentrated mainly in the kidney and pituitary. TRH was eliminated partly by the kidney and 21.9% was excreted within 2h after intravenous injection.
