Anti-inflammatory Effect of High-dose Glucocorticoid and Its Mechanism during Cardiopulmonary Bypass in Rabbits
- VernacularTitle:大剂量糖皮质激素对体外循环兔的抗炎作用及其机制
- Author:
Weiyong YU
;
Baoren ZHANG
;
Renbao XU
;
Kaihua CAI
- Publication Type:Journal Article
- Keywords:
cardiopulmonary bypass;
glucocorticoid;
phospholipases A;
extravascular lung water;
animal;
rabbits
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of high-dose glucocorticoid (GC) on plasma phospholipase A2 (PLA2) activity, extravascular lung water (EVLW) and lung pathology during cardiopulmonary bypass (CPB) was studied on the CPB model in rabbits. The results showed that both plasma PLA2 activities and EVLW increased significantly during CPB, and there was a significant correlation between EVLW and plasma PLA2 activities at 90 min of CPB (r = 0. 8439, P
