The release of polyamines and excitatory amino acid during cerebral ischemia and reperfusion
- VernacularTitle:脑缺血再灌流后多胺与兴奋性氨基酸的释放
- Author:
Caimei ZHENG
;
Honghua LI
;
Zhiyong LU
- Publication Type:Journal Article
- Keywords:
polyamines;
amino acids;
reperfusion injury;
MK-801
- From:Journal of Third Military Medical University
1983;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The dynamic changes of the contents of polyamines and excitatory amino acid in the hippocampus during cerebral ischemia and reperfusion were observed in rats.It was found that the content of putrescine was increased and the release of excitatory amino acid elevated during reperfusion,and the increase of putrescine could be stopped when the antagonist of NM-DA receptor of excitatory amino acid,that is,MK-801,was administered.These facts suggest that the metabolic disturbance of polyamines in closely related to the release of excitatory amino acid and modulated by NMDA receptors.The combination of polyamines with excitatory amino acid may play an important role in the ischemic damage of the brain.
