Effects of pineal melatonin on chemiluminescence of peritoneal macrophages and PGE_2 content in the hypothalamus and spleen in rats
- VernacularTitle:松果腺褪黑素对大鼠腹腔巨噬细胞化学发光和脾、下丘脑PGE_2含量的影响
- Author:
Changhai DING
;
Wei WEI
;
Shuyun XU
- Publication Type:Journal Article
- Keywords:
pineal gland;
melatonin;
pinealectomy;
chemiluminescence;
PGE_2;
radioimmunoassay
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Pinealectomy (PX), zymosan-in-duced-luminol-dependent-chemiluminescence (CL) and PGE2 radioimmunoassay were used to determine the effects of the pineal gland and melatonin ( MT ) on CL of peritoneal macrophages (PM?s) and PGE2 content in the hypothalamus and spleen in rats. It was suggested that the CL value of PM?s was decreased and PGE2 contents in the hypothalamus and spleenwere increased significantly after PX, which could be restored respectively by 10~ 1 000 ?g? kg-1MT and 10 ?g?kg-1MT. 10 ?g?kg-1MT could also inhibit PGE2 in the hypothalamus and spleen in normal rats.
