Effects of flavonoids of glycyrrhiza on ethanol-induced liver injury in mice
- VernacularTitle:甘草类黄酮对乙醇所致小鼠肝脏损伤的影响
- Author:
Gensheng WANG
;
Zhewu HAN
- Publication Type:Journal Article
- Keywords:
flavonoids of glycyrrhiza;
ethanol;
liver injury;
lipid peroxidation
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of Flavonoids of Gly-cyrrhiza (FG) on ethanol-induced liver injury was studied in mice. Administration of FG to mice prior to ethanol treatment ,either once daily for four days or a single dose, the increase of malondialdehyde and the decrease of reduced glutathione were inhibited dose- dependently.Electron microscopic examination showed that the ethanol-induced damage of hepatocytes could be ameliorated by FG pretreatment. However, no protective effect was observed when FG was administrated to mice after ethanol intoxication.
