THE ACUTE LUNG INJURY INDUCED BY E.COLI ENDOTOXIN AND THERAPEUTIC EFFECT OF PROSTAGLANDIN E_1 IN RABBITS
- VernacularTitle:内毒素致家兔急性肺损伤及前列腺素E_1治疗作用的研究
- Author:
Jianxin WANG
;
Nianqiu HUANG
;
Zhongsu ZHAO
;
Yi SHI
;
Meifang YANG
;
Weihua LI
- Publication Type:Journal Article
- Keywords:
Endotoxin;
Lung injury;
PGE_1;
TXA_2;
PGI_2;
Respiratory distress syndrome
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
A model of acute lung injury was reproduced by intravenous injection of endotoxin (700?g / kg) to rabbits. It had been found that the rabbits were in the state of shock, with leukopenia and thrombocytopenia, increased 6 -keto-PGF1? and TXB2, decreased serum ACE and increased permeability of the pulmonary capillaries. Granulocyte sequestration and disturbance in pulmonary microcirculation were found in lungs. A series of changes in epithelial and endothelial cells were also found in both lungs. It was obviously proved that PGE1 had some therapeutic effects in acute lung injury induced by E. coli endotoxin.
