Synthesis and antifungal, antibacterial properties of some fluorosalicylanilide derivatives
- Author:
Truong -- Phuong
- Publication Type:Journal Article
- Keywords:
fluorosalicylanilide derivatives
- MeSH:
Pharmaceutical Preparations;
Antifungal Agents;
Anti-Bacterial Agents
- From:Pharmaceutical Journal
2004;0(9):21-25
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The synthesis of some flourosalicylanilid derivatives and the study on their antifungal activities were performed as regard the synthesis: Acid- 4 aminosalcylic was diazoidized, then reacted to NaBF4 solution- Acid 4- flourosalicyanilid was created. Acid 4- fluorosalicylic and salicylic acid were condensed to aniline derivatives for creating 9 derivatives of fluorosalicylic. The synthetized substances were purified, fusion point and thin layer chronatography were determined. In products antibacterial inanifested and antifungal were in experimental concentration. Relatively strong activity of 3'- flourosalicyanilid had exerted on S. aureus; MRSA at the concentration of 9 microgram/ml and 18 microgram/ml; and 3'- flourosalicyanilid, 4'- flourosalicyanilid reacted relatively strongly on Microsporum nanum, Trichophyton mentagrophyle. Microsporum gypseum at the concentration of 2 microgram/ml and microgram/ml
