Effects of BN50739, a PAF Antagonist, on Early Reperfusion-induced Arrhythmia in Rats
- VernacularTitle:血小板激活因子受体拮抗剂BN50739对大鼠早期再灌注心律失常的作用
- Author:
Rongliang XU
;
Tonghua ZHANG
;
Hongjun DING
- Publication Type:Journal Article
- Keywords:
platelet-activating factor;
myocardial ischemia;
reperfusion;
arrhythmia;
animal;
rats
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The present study investigated the effect of BN50739, a new PAF antagonist, on the early reperfusion-induced arrhythmia in anesthetized SD rats, and by this to elucidate the role of PAF in the mechanism of early reperfusion-induced arrhythmia. The results indicated that the BN50739 group had lower incidences of premature ventricular contraction (PVQ, ventricular tachycardia (VT) and ventricular fibrillation (VF) during reperfusion than the control group (58.3% vs 66.7%, 50% vs 77.8%, and 16.7% vs 88.9%). But only VF incidence had a significant difference. Also the BN50739 group had shorter duration of VT+VF and of total arrhythmias than control group (58.8+171.9 vs 296.4+291.4, and 76.4+173.9 vs 361.8 + 286.5, P
