Analysis of Nuclear DNA Content in Breast Tumours
- VernacularTitle:乳腺肿瘤细胞核DNA含量分析
- Author:
Weiqiang ZHENG
;
Rongzhou ZHAN
;
Lianfu ZUO
;
Jianwen GUO
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
DNA;
flow cytometry;
pathology;
human;
female
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear DNA content in 103 cases of malignant and benign breast tumours were determined by means of flow cytometry. It was found that DNA in all the benign lesions showed diploids. In contrast, only 32.3 percent of the cancers had diploids, while 62.3% had additional DNA aneuploids including near-diploids (18.4%); triploids (22.3%); and tetraploids (8.2%) etc. Both the cellular proportion in S-phase and DNA index were significantly higher in malignant breast tumours than those in benign ones (P0.05). The results indicate that the analysis of DNA content is a useful and objective adjunct in the assessment of proliferative activity and biological behavior on breast tumour.
