Changes of Serum Gastrin Levels in Rats during Chemical Induction of Colorectal Cancer
- VernacularTitle:化学诱导大鼠大肠癌时血清促胃液素的变化
- Author:
Ronghua ZHAO
;
Yuanhe WANG
;
Yuhong WANG
;
Teng CHEN
;
Han GAO
- Publication Type:Journal Article
- Keywords:
cancer, large intestinal;
gastrin;
carcinogen;
animal;
rats
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The dynamic changes of serum gastrin (SG) levels were observed in rats during chemical induction of colorectal cancer by 1,2-dimethylhydrazine (DMH). It was found that the mean SG concentration in the induced rats was very significantly lower than that in the control rats (P0.05) from week 11 to 20 after induction;the mean SG concentration in the induced rats with colorectal cancer in Dukes A or B stage was very significantly higher than that in those without cancer or with cancer in Dukes C or D stage (P
