Toxic Effects of Hematoporphyrin Monoether——PsD-044 on Ocular Tissue
- VernacularTitle:新型肿瘤光化学诊治剂血卟啉单甲醚的眼组织光毒作用
- Author:
Yajun PENG
;
Shufang HE
;
Wei ZHAO
;
Chuangui HAN
;
Nianci SHEN
- Publication Type:Journal Article
- Keywords:
hematoporphrin derivative;
hematoporphyrin monoether;
phototoxicity;
ciliary body;
retina;
optic nerve;
animal;
dogs
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The histopathological changs of the dog eyes caused by acute and subacute toxic effectsof hematoporphyrin monoether--PsD-044 were observed in this research. The results showed thatPsD-044 could lead to keratoscleritis and scleral perivasculitis. Phototoxic cyclitis and inflammatory edema of the retina were more serious in deferred killed animals, suggesting that it is necessary to avoid exposure to light after the administration of PsD-044.
