A study on antigen receptor gene rearrangements in 13 cases of T-cell non-Hodgkin's lymphoma
- VernacularTitle:T细胞性NHL抗原受体基因重排分析
- Author:
Jianzhong ZHANG
;
Yan BAI
;
Liangsui YAN
;
At ET
- Publication Type:Journal Article
- Keywords:
lymphoma;
non-Hodgkin's;
gene rearrangement;
blotting;
Southern;
poly-merase chain reaction
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The beta and gamma chain gene rearrangements of the T-cell receptors(TCR)were studied with Southern blot hybridization and polymerase chain reaction in 13 cases of non-Hodgkin's lymphoma with T-cell phenotype.It was found that 11 out of the 13 cases(86%)exhibited TCR beta gene rearragnement and 12 out of the 13(91%)displayed TCR gamma gene rearrangement.The findings suggest that gene rearrangements are more sensitive and specific markers to establish T-cell monoclonality and lineage and helpful to the morphological diagnosis and immunophenotyping for non-Hodgkin's lymphoma.
