A study on p53 and Rb genes in gastric cancer and juxta-cancerous tissue
- VernacularTitle:胃癌及癌旁组织中p53基因和Rb基因的研究
- Author:
Junru WANG
;
Weiwen LIU
;
Bing WANG
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
oncogenes;
p53 genes;
Rb genes
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The deletion and rearrangement of p53 and Rb genes were studied in gastric cancer with Southern blot hybridization and the point mutation in 248 and 249 codons of p53 was studied with PCR-RFLP.It was found that deletion or rearrangement of p53 was seen in 9 cases out of 30 cases of gastric cancer and point mutation at 248 codon of p53 in 2 cases out of 42 cases,and deletion and rearrangement of Rb gene were seen in 2 cases out of 15 cases.
