Effects of electroacupuncture on hippocampal epileptic burst discharges induced by intracerebroventricular injection of kainic acid in the rat
- VernacularTitle:电针对大鼠侧脑室注入红藻氨酸所致海马痫样丛状放电的影响
- Author:
Zhengzhi FENG
;
Weihong LIAO
- Publication Type:Journal Article
- Keywords:
epilepsy;
kainic acid;
hippocampus;
rats;
burst discharges
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Epilepsy induced by intracerebroventricular injection of kainic acid in the rat could be attenuated by electroacupuncture(EA)at the "Du Mo point" since EA resulted in a reduction of the frequency and amplitude of the hippocampal EEG especially in the 1st min after EA.No unsynchronization of the hippocampal EEG occurred before or after EA.The hippocampal unit discharges after intracerebroventricular injection of kainic acid were classified into positive units,negative units and indifferent units,The positive units were inhibited by EA while the negative units,on the contrary,were activated.The positive units(21%)and the indifferent units(33%)were converted into negative units by EA.At the same time,EA reduced the NSEB value and IBSF value of hippocampal epileptic burst discharges.On the basis of these findings,it is believed that the inhibition of the amplitude of hippocampal epileptic EEG by EA plays an important role of the antiepileptic action of EA,hippocampal negative units are one of the factors of antiepileptic action,and EA can regulate the intrinsic characteristics of epileptic neurones.
