The effect of fructose-1,6-diphosphate on cardiac function and endorphin in acute myocardial ischemia in rats
- VernacularTitle:1,6二磷酸果糖对急性心肌缺血大鼠心功能及内啡肽的影响
- Author:
Xiaoyan LI
;
Chenghai WANG
;
Changlin LU
- Publication Type:Journal Article
- Keywords:
beta-endorphin;
myocardial ischemia;
radioimmunassay;
fructose - 1,6 - diphosphate
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
In this study, acute cardiac ischemia was induced by ligation of the anterior descending branch of the coronary artery in rats. Radioimmunoassay was conducted to measure the contents of immunoreactive beta - en-dorphin (ir-?-EP)after ischemia and fructose -1,6 - diphosphate (FDP) treatment. Results showed that the contents of ir-?-EP were in-cereased in the plasma, some brain areas, pituitary and myocardium after ligation of the left coronary artery of the rats which resulted in the deterioration of the cardiac function includingdp/dtmax, Lvsp, total areas of force loop and blood pressure. Intravenous administration of FDP improved cardiac function and reduced the contents of ir - ? - EP in the above mentioned tissues suggesting that ir-?-EP correlate closely with cardiac function after ischemia,the reduction of which was possibly involved in the improve ment of cardiac function by FDP.
