The inhibition of propafenone on 0 phase depolaeization of the action poential from neonatal and adult canine purkinje fibres
- VernacularTitle:心律平对不同年龄犬心肌浦氏纤维零期去极化的抑制
- Author:
Liying HAO
;
Hui XU
;
Jinming LI
- Publication Type:Journal Article
- Keywords:
propafenone;
microelectrode;
neonatal canine;
adult canine;
purkinje fibres;
0 phase depolariztation
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of 5.8 ////mol L-1 propafeone on 0 phase depolarization of action potential were studed in meonatal and adult canine Purkinje fibres. Results showed: 1. in both groups, propafenone caused a reduction if APA and a decrease of Vmax; and the neonatal fibres were less sensitive to propafenone; 2. the inhibition of Vmax by propafenone showed frequency-dependent manner in both groups; and with theincrease of frequencies, the extent to which Vmax was inhibited became similiar in both groups. This sudy suggests that neonates were less sensitive to propafenone, but at higher frequencies neonates showed similiar responses as adults.
