Studies on the exponentially declining infusion and the program infusion of theophyl ine in rabbits
- VernacularTitle:茶碱指数衰减滴注及程序输注的研究
- Author:
Shiming DUAN
;
Xun XU
;
Huifang HUANG
- Publication Type:Journal Article
- Keywords:
theophyline;
esponentially declining infusion;
program infusion;
pharmacoki-netics
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Constant infusion, exponentially declining infusion and program infusion of theophlline were administered to rabbits byadopting the rabbit population pharmacokinetic parameters in this laboratory, and the plasma concentrations of the drug was measured by ul- traviolet spectrophotometry. The results showed that the plasma drug concentrations following exponentially declining infusion and program infusion attained the desired steady-state level at only 30 min, though the T1/2?= 6. 08h, The median absolute value of performance error in pro-gram infusion and exponentially declining infusion was 7. 8% and 14% respectively.
