Pharmacological studies on poly-saccharide sulphate: protective effects on experimental myocardial infarction in rabbits and myocardial necrosis induced by isoprenaline in rats
- VernacularTitle:藻酸双酯钠对实验性心肌梗塞动物缺血性损伤的保护作用
- Author:
Sai LIU
;
Chunbo WANG
;
Shenbo GUO
- Publication Type:Journal Article
- Keywords:
PSS;
isoprenaline;
myocardial infarction
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
This study reported the protective effects of poly-saccharide sulphate (PSS) on experimental model of myocardial infaction by high positioned double - ligation of the anterior descending left coronary artery in rabbits, and on ischemic injury of myocardium by intraperi-toneal injection of isoprenaline in rats. The results showed that PSS could decrease the infarct sizes of rabbits model expressed by ECG mappingof ∑ST segment, NST and NQ, and reduce the activities of CPK in serum. It also showed that PSS reduced the severity of myocardial necrosis and the activies of CPK in serum of the experimental rats . It suggested that PSS have the protective effects on ischemic injury of myocardium.
