Effects of Nitrendipine and Tetrandrine on ?-Aminobutyric Acid Contents in Hypothalamus of Spontaneously Hypertensive Rats
- VernacularTitle:尼群地平和粉防己碱对自发性高血压大鼠下丘脑?-氨基丁酸含量的影响
- Author:
Ying GUAN
;
Weifei FU
;
Qianzhou LU
;
Ming YIN
;
Quanying ZHU
;
Dingfeng SU
- Publication Type:Journal Article
- Keywords:
nitrendipinc;
tetrandrine;
antihypertension agents;
hypothalamus;
?-aminobutyric acid;
hypertension;
rats
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of nitrendipine (Nit) and tetrandrine (Tet) on the contents of ?-aminobutyric acid (GABA) in the hypothalamus and cortex were studied in spontaneously hypertensive rats (SHR). The results showed that short-term (1 week) and long-term (20 weeks) treatments with Nit and Tet produced a decrease in blood pressure and an increase in GABA contents in the hypothalamus but not in the cortex. These findings suggest that the action of Nil and Tet on GABA contents in the hypothalamus may be partially contributed to their antihypertensive effects.
