Effects of Long-term Antihypertensive Treatment on the Function of Endothelium- dependent Relaxation in Spontaneously Hypertensive Rats
- VernacularTitle:长期使用抗高血压药物对大鼠血管内皮依赖性松弛功能的影响
- Author:
Qianzhou LU
;
Chuoyu MIAO
;
Quanying ZHU
;
Dingfeng SU
- Publication Type:Journal Article
- Keywords:
antihypertensive agents;
hypertension;
aorta;
endothelium-dependent relaxation;
rats
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of long-term treatments with 7 antihypertensive agents on the functions of endothelium-dependent relaxation were studied in spontaneously hypertensive rats (SHR). It was found that captopril, atenolol and dihydrochlorothiazide (DHT) could prevent the endothelium in SHR from impairing, but tetrandrine, nitrendipine, prazosin and dihydralazine could not. The improvement of the function of endothelium-dependent relaxation was not related to the blood pressure lowing.
