Assay of antigens with anti-lung cancer McAb 3C_9 and preliminary evaluation of serological diagnosis for lung cancer
- VernacularTitle:抗肺癌单抗3C_9识别的抗原检测及其血清诊断价值初步探讨
- Author:
Xuefeng BAI
;
Dengshun WANG
;
Xianjian GUO
- Publication Type:Journal Article
- Keywords:
lung neoplasms;
tumor markers,biological;
antibodies ,monoclonal
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The antigens(3C9Ag)which could be recognized by the anti-lung cancer monoclonal antibody 3Ca were assayed with BA-ELISA immunobinding inhibition test in 50 lung cancer patients,21 patients with non-cancerous pulmonary diseases and 40 normal subjects.Meanwhile radioimmunoassay was used to determine serum CEA.It was found that the sensitivity,specificity and accuracy for 3C9Ag to diagnose lung cancer were 76%,90.5% and 80.3% respectively.Much higher positive rates could be found in NSCLC patients and in those with stage Ⅱ or Ⅲ cancer.3CsAg was superior to CEA in its sensitivity and accurracy.Combined assay with 3C9Ag and CEA could increase the positive rate.
