Effects of endotoxin on protein catabolism of skeletal muscles in severe scalding rats
- VernacularTitle:内毒素对大鼠严重体表烫伤早期骨骼肌蛋白质分解代谢的影响
- Author:
Changbao ZHOU
;
Yanlin DONG
;
Min CHEN
- Publication Type:Journal Article
- Keywords:
burns/AN;
muscle protein;
protein catabolic rate;
soleus muscle
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to study the role played by infection in the occurrence and mechanism of negative nitrogen balance of the skeletal muscles in the early stage of scalding,37% TBSA full thickness scalding was inflicted on the back and one hind leg of rats and the protein catabolic rate in the soleus muscle of both the scalded and healthy legs was determined and the effects of endotoxin on the catabolic rate were observed.It was found that the protein catabolic rate was markedly accelerated in the scalded soleus 3 days after iujusy;and showed no significant changes in the healthy one,in which the protein catabolic rate was near or similar to that of the normal control.After 2 mg/kg of endotoxin was administered intraperitoneally.the findings were as follows:(1)Endotoxin could also accelerate the protein catabolic rate in the skeletal muscles;(2)The protein catabolic rate in the scalded soleus was not further increased and no summation effect of scalding and endotoxin on protein catabolism occurred.
