The effect of ischemia-reperfusion injury on concentrations of free amino acids in rat myocardium and taurine's protective role
- VernacularTitle:缺血—再灌注损伤对大鼠心肌中氨基酸的影响及牛磺酸的保护作用
- Author:
Junyi GU
;
Jing LI
;
Shu LU
- Publication Type:Journal Article
- Keywords:
taurine;
heart;
ischemia-reper- fusion;
rat
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
By using the model of ischemia-reperfusion injury in the isolated working rat heart,the change of free amino acid concentrations in myocardium and the effect of taurine on the heart were investegated. It was found that concentrations of 17 free amino acids in myocardium, except Cys,decreased,and that 20mM taurine was able to ameliorate the ischemia-reperfusion injury of the heart ;e. g. , the improvement of recovery of cardiac mechanical functions, the decrease in the leakage of LDHand CK from myocardium,in the accumulation of lipid peroxides and calcium,and in the loss of free amino acids in myocardium,as well as the decrease in the occurence rate of ventricular arrhythmias during the reperfusion phase. So, it may be suggested that exogenous taurine has some protective effects against the myocardial is-chemia-reperfuaion injury.
