The effect of tranilast on the down-regulation of beta-adrenoceptors
- VernacularTitle:曲尼司特对豚鼠肺组织?肾上腺素受体向下调节的影响
- Author:
Yu YANG
;
Kaisheng YIN
;
Ming YANG
- Publication Type:Journal Article
- Keywords:
tranilast;
terbutaline;
asthma;
beta adrenergic receptor
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of tranilast on the down- regulation of beta- adrenoceptor agonist was investigated. Male guinea pigs were divided into 3 groups, one group is control. Others were received injection of terbutaline or terbutaline plus tranilast for successive 5 days. The radioli-gand binding assays for beta-adrenoceptors in the lung membranes of the guinea pigs were per-formed. The results showed the numbers of maximal binding sites (Bmax) of beta-adrenoceptors in terbutaline group was significantly less than that in control group ( P 0. 05).The affinity ( Kd) of beta-adrenoceptors both in terbutaline group and in terbutaline plus tranilast group was higher than that in control (P
