Establishment of multidrug resistance to adriamycin in Ehrlich ascites carcinoma in vivo
- VernacularTitle:阿霉素对艾氏腹水癌细胞产生多药抗药性的研究
- Author:
Qingduan WANG
;
Meijun LIU
;
Guodong LI
- Publication Type:Journal Article
- Keywords:
adriamycin;
multidrug resistance;
cross resistance;
ehrlich ascites carcinoma;
oridonin
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Resistance to adriamycin was developed in an orignally adriamycin- sensitive strain of Ehrlich ascites carcinoma (EAC) in vivo by treament with the adriamycin during 50 weekly passages of the tumor. The results showed that the growth of the resistant line was slower than that of the EAC, total ascites cell volume,total cell number and mean single-cell volume were significantly smaller of the resistant line than those of original sensitive line. Also, itwas found the homogerously staining region and double minute chromosome in the cells of resistant line. The adriamycin-resistant tumor produced cross resistance to vincristine.mitomycin C,and actinomycin D,while section resistance to VP-16. There was no change in the sensitivity of tumor to oridonin.
