The influences of xylazine on the gastrointestinal motility in mice and on the gastrointestinal electrical rhythm in rats
- VernacularTitle:赛拉嗪对小鼠胃肠运动及大鼠胃肠电的影响
- Author:
Liang MING
;
Guansu XU
;
Yu WANG
- Publication Type:Journal Article
- Keywords:
xylazine;
Yohimbine;
idazoxan;
gastrointestinal propulsive motility;
gastrointestinal basic electrical rhythm
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Yohimbine (0. 5~4mg ? kg-1, sc) and idazoxan (2~8 mg ? kg-1,sc) showed a dose related antagonistic action on the inhibitory effect of xylazine (4mg ? kg-1,sc) on the gastrointestinal propulsive motility in mice. Xylazine (2mg,4mg ? kg-1,sc),clonidine(120 ?g ? kg-1,sc) exhibited the inhibitory effect of gastrointestinal basic electrical rhythm on the stomach, duodenum, jejunum and ileum in rats.The inhibitory effects of these drugs were the strongest at 30 min after administration of Compounds. Yohimibine (4mg ? kg-1,sc) was found to antagonize the inhibitory effect of xylazine (4mg ? kg-1,sc) on the gastrointestinal basic electrical Rhythm.
